Beilstein J. Org. Chem.2021,17, 229–233, doi:10.3762/bjoc.17.23
subsequent decarboxylative trifluoromethylthiolation were performed in a one-pot fashion.
Keywords: decarboxylation; fluorinated compounds; pyridinecompounds; trifluoromethylthiolation; Introduction
The pyridine ring is found in numerous biologically active compounds. Therefore, efficient methods for
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Graphical Abstract
Scheme 1:
Electrophilic decarboxylative functionalization of 2-pyridylacetates.
Beilstein J. Org. Chem.2014,10, 1421–1432, doi:10.3762/bjoc.10.146
to the natural compound, now called streptopyridine E. The mass spectra of 2-(pent-1-enyl)pyridine and 2-(pent-2-enyl)pyridine, compounds synthesized for comparison, are shown in Supporting Information File 1 and differ from that of 8. Finally, pyridines 6 and 7 were synthesized also by Fürstner
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Graphical Abstract
Figure 1:
Alkaloids produced by Streptomyces strain FORM5.